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Tolterodine drug interactions

What are possible side effects of Detrol? Upjohn Company September, 2008. Advise patients to swallow ER capsule whole. omeprazole

DETROL LA is right for you

No mutagenic or genotoxic effects of tolterodine were detected in a battery of in vitro tests, including bacterial mutation assays Ames test in 4 strains of Salmonella typhimurium and in 2 strains of Escherichia coli, a gene mutation assay in L5178Y mouse lymphoma cells, and chromosomal aberration tests in human lymphocytes. Tolterodine was also negative in vivo in the bone marrow micronucleus test in the mouse. The extended release formulation should be swallowed whole. Tolterodine is rapidly absorbed; bioavailability is at least 77%. T max is within 1 to 2 h immediate release and 2 to 6 h ER. Food increases bioavailability approximately 53% of immediate-release tolterodine, but has no effect on ER tolterodine.

What are the ingredients in DETROL?

Renal impairment can significantly alter the disposition of tolterodine immediate-release and its metabolites. Extended-release versions of these drugs may help reduce side effects. Following administration of a 5 mg oral dose of 14C-tolterodine solution to healthy volunteers, 77% of radioactivity was recovered in urine and 17% was recovered in feces in 7 days. Tomas L. Griebling, MD, MPH. He is vice chair of the department of urology at the University of Kansas. Use a restroom whenever you have the chance, whether or not your bladder feels full, he says. The main effects of tolterodine at 1 and 5 hours were an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure. These findings are consistent with an antimuscarinic action on the lower urinary tract.

Tolterodine code

Effect of tolterodine on other drugs metabolized by Cytochrome P450 enzymes: Tolterodine immediate release does not cause clinically significant interactions with other drugs metabolized by the major drug-metabolizing CYP enzymes. In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole. Taking many trips to the bathroom only to urinate just a little bit each time. TEVA” in bottles of 30 NDC 0093-7164-56 90 NDC 0093-7164-98 and 500 NDC 0093-7164-05.



Tolterodine forms and strengths

This may not be a complete list of all interactions that may occur. Ask your health care provider if Detrol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. If you are breast-feeding. It is not known if tolterodine tartrate passes into your breast milk or if it can harm your baby. Talk to your doctor about the best way to feed your baby if you take Tolterodine Tartrate Tablets. Tolterodine Tartrate Tablets are associated with anticholinergic central nervous system CNS effects including dizziness and somnolence see . Patients should be monitored for signs of anticholinergic CNS effects, particularly after beginning treatment or increasing the dose. Ruscin JR, Morgenstern NE. Tolterodine use for symptoms of overactive bladder. Ann Pharmacother. EM and poor PM metabolizers is provided in Table 1. These data were obtained following single and multiple doses of tolterodine 4 mg administered twice daily to 16 healthy male volunteers 8 EM, 8 PM. Who should not take tolterodine tartrate extended-release capsules? DETROL 2 mg bid. Have a condition called myasthenia gravis. DETROL Tablets contain tolterodine tartrate. Patients should be informed that antimuscarinic agents such as tolterodine tartrate extended-release capsules may produce the following effects: blurred vision, dizziness, or drowsiness. Patients should be advised to exercise caution in decisions to engage in potentially dangerous activities until the drug's effects have been determined. If any of these effects persist or worsen, tell your doctor or promptly. WebMD Information and Resources: "Cystoscopy. This leaflet summarizes the most important information about Tolterodine Tartrate Tablets. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about Tolterodine Tartrate Tablets that is written for health professionals. You can also call 1-877-446-3679 1-877-4-INFO-RX. Fusidic Acid Systemic: May increase the serum concentration of CYP3A4 Substrates.



Does tolterodine interact with other medications

There are no studies of tolterodine in pregnant women. Therefore, tolterodine tartrate extended-release capsules should be used during pregnancy only if the potential benefit for the mother justifies the potential risk to the fetus. Pharmacokinetic differences due to race have not been established. Liver impairment can significantly alter the disposition of tolterodine immediate-release. Do not stop taking any medications without consulting your healthcare provider. Some medical conditions may interact with mirabegron. Keep Tolterodine Tartrate Tablets and all medicines out of the reach of children. What are Tolterodine Tartrate Tablets? These included a total of 1012 patients 505 randomized to tolterodine tartrate extended-release capsules, 4 mg once daily and 507 randomized to placebo enrolled in a randomized, placebo-controlled, double-blind, 12 week clinical efficacy and safety study. Some clinicians recommend administering tolterodine tartrate in a consistent manner relative to food intake. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of 5-hydroxymethyl tolterodine 5-HMT the major pharmacologically active metabolite. 5-HMT, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and 5-HMT exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Overactive bladder happens when you cannot control your bladder muscle. When the muscle contracts too often or cannot be controlled, you get symptoms of overactive bladder, which are leakage of urine urge urinary incontinence needing to urinate right away urgency and needing to urinate often frequency. Your doctor will tell you how many Detrol Tablets to take and when to take them. Gotta go all the time? Dunn, now 60, tells WebMD. When her children were younger, they would all be out and about, and the outing would often be interrupted by a quick trip home after Dunn had an accident. In people with overactive bladder, muscles in the bladder wall contract at the wrong time. Dabrafenib: May decrease the serum concentration of CYP3A4 Substrates. Management: Seek alternatives to the CYP3A4 substrate when possible. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely particularly therapeutic effects. amitriptyline



Tolterodine overdose

Taking a road trip? The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Keep Detrusitol out of the sight and reach of children. You can take DETROL with or without food. The offspring regained the weight during the maturation phase. It is not known whether tolterodine is excreted in human milk; therefore, Tolterodine Tartrate Tablets should not be administered during nursing. A decision should be made whether to discontinue nursing or to discontinue Tolterodine Tartrate Tablets in nursing mothers. icla.info metformin



Tolterodine side effects

Myasthenia gravis: Use with caution in patients with myasthenia gravis. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. If you miss a dose of mirabegron, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses on the same day. If your overactive bladder hasn't improved with lifestyle changes and medicines and you don't want to have surgery, percutaneous tibial nerve stimulation PTNS is an option. Side effects were least often reported by people taking the drug solifenacin. Renal impairment can significantly alter the disposition of tolterodine and its metabolites. Potent CYP3A4 inhibitors: The effect of a 200 mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate release was studied in 8 healthy volunteers, all of whom were CYP2D6 poor metabolizers. Administer tolterodine tartrate extended-release capsules with caution in patients with gastrointestinal obstructive disorders because of the risk of gastric retention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Always consult your doctor if you are thinking of stopping the treatment. Anticholinergics aren't right for everyone. PO For patients currently taking potent inhibitors of CYP3A4 eg, ketoconazole, clarithromycin, ritonavir the recommended dosage is 2 mg once daily ER or 1 mg twice daily immediate release. cost of loratadine walgreens



Pain or burning when you urinate

Guay DRP. Tolterodine, a new antimuscarinic drug for treatment of bladder overactivity. Pharmacotherapy. PO 1 mg twice daily. You are allergic to TOVIAZ, which contains fesoterodine. Bladder retraining. This involves increasing the intervals between using the bathroom over the course of about 12 weeks. This helps retrain your bladder to hold urine longer and to urinate less frequently. Bozeman says. About 75% of OAB patients get improvement on the medications. "I have plenty of patients who are on medication and haven't had an accident since. Consortium for Spinal Cord Medicine 2006. Bladder management for adults with spinal cord injury. DETROL may cause allergic reactions that may be serious. slimex



PO 2 mg once daily

Dunn sought medical attention for her years ago, but nothing seemed to help, until she entered a study in April 2006 at the University of Pittsburgh. This information is generalized and not intended as specific medical advice. Little or no activity at α-adrenergic receptors, histaminergic receptors, calcium-channel receptors, and the neuromuscular junction. The sums of unbound serum concentrations of tolterodine and 5-HMT are only 25% higher during the interaction. Patients should be informed that antimuscarinic agents such as Tolterodine Tartrate Tablets may produce the following effects: blurred vision, dizziness, or drowsiness. Patients should be advised to exercise caution in decisions to engage in potentially dangerous activities until the drug's effects have been determined. DETROL and get emergency medical help right away. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tolterodine in the elderly. However, elderly patients are more likely to have age-related kidney or liver problems, which may require an adjustment in the dose for patients receiving tolterodine. Tolterodine tartrate is a white, crystalline powder. The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients than in the healthy volunteers. For patients with mild to moderate hepatic impairment Child-Pugh Class A or B the recommended dose for tolterodine tartrate extended-release capsules is 2 mg once daily. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The remainder of the population is referred to as "extensive metabolizers. MedlinePlus Medical Encyclopedia: "Urinalysis. You have trouble emptying your bladder also called “urinary retention”.



What are the possible side effects of tolterodine

Drowsiness and confusion can increase the risk of falling. Pharmacokinetics of immediate-release tolterodine have not been established in pediatric patients. Dose-plasma concentration relationship was linear over the range of tolterodine ER doses assessed. Dry mouth 35%; constipation 7%; abdominal pain 5%; diarrhea, dyspepsia 4%. Tolterodine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. An extra patient leaflet is available with Detrol. Talk to your pharmacist if you have questions about this information. Detrol, like other antimuscarinic drugs, should be used with caution in patients with decreased gastrointestinal motility. Do NOT take more than the recommended dose without checking with your doctor. You can take Tolterodine Tartrate Tablets with or without food. You may not be able to hold your urine until you get to the bathroom. Is your urine darker or lighter than usual? C. Protect from light. Keep in a dry place. PO 2 mg once daily. Among the tales, Bozeman says, is a woman who was dancing at her wedding and suddenly there was a puddle on the floor. Renal impairment: Use with caution in patients with renal impairment; dosage adjustment is required. augmentin capsules



Prescribing information for tolterodine

An urgent need to urinate. This information should not be used to decide whether or not to take mirabegron or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about mirabegron. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to mirabegron. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using mirabegron. Has occurred when tolterodine was used at higher than recommended doses and was more pronounced in CYP2D6 poor metabolizers. Consider this when prescribing to patients with a known history of QT prolongation or in patients taking class IA eg, quinidine, procainamide or class III antiarrhythmics eg, amiodarone, sotalol. What are the ingredients in DETROL? Tolterodine tartrate extended-release capsules are contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma. Know when to use Kegels. This dose did not result in any embryotoxicity or teratogenicity. There are no studies of tolterodine in pregnant women. Therefore, Tolterodine Tartrate Tablets should be used during pregnancy only if the potential benefit for the mother justifies the potential risk to the fetus. It will still only be available in prescription form for men. National Center of Biotechnology Information: "Comparing Drugs for Overactive Bladder Syndrome. The first step in treatment will be to try some things at home, such as urinating at scheduled times. Anon. Tolterodine for overactive bladder. Med Lett Drugs Ther. Cmax and a 20% decrease in AUC of the 5-hydroxymethyl metabolite. Absorption: In a study with 14C-tolterodine solution in healthy volunteers who received a 5 mg oral dose, at least 77% of the radiolabeled dose was absorbed. C max and area under the concentration-time curve AUC determined after dosage of tolterodine immediate release are dose-proportional over the range of 1 to 4 mg. Based on the sum of unbound serum concentrations of tolterodine and 5-HMT “active moiety” the AUC of tolterodine extended release 4 mg daily is equivalent to tolterodine immediate release 4 mg 2 mg bid. C max and C min levels of tolterodine extended release are about 75% and 150% of tolterodine immediate release, respectively. Maximum serum concentrations of tolterodine extended release are observed 2 to 6 hours after dose administration. The adverse events are reported regardless of causality. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. purchase anastrozole for



Tolterodine brand names

Keep DETROL LA and all medicines out of the reach of children. Or it could signal a health problem. Plan ahead to locate public restrooms. For example, the National Association for Continence web site has a tool called "Find a Bathroom. Use is not recommended; has not been studied. Neurological Tests. Diagnostic tests and procedures that help the doctor confirm or rule out the presence of a nerve disorder. The tablets are for oral use and should be swallowed whole. Two pediatric phase 3 randomized, placebo-controlled, double-blind, 12-week studies were conducted using tolterodine extended release Detrol LA capsules. discount clomiphene medicamento



What other drugs will affect tolterodine

Simeprevir: May increase the serum concentration of CYP3A4 Substrates. Research reports that using anticholinergics results in fewer spasms of the bladder muscle and thus fewer accidents. The bladder may also be able to hold more urine. Because these spontaneously reported events are from the worldwide post-marketing experience, the frequency of events and the role of tolterodine in their causation cannot be reliably determined. Timed voiding helps people who have a condition that makes it hard for them to get to a bathroom in time, such as a physical disability. The person follows a schedule with set times to visit the restroom. Secretin: Anticholinergic Agents may diminish the therapeutic effect of Secretin. Management: Avoid using drugs with substantial anticholinergic effects in patients receiving secretin whenever possible. If such agents must be used in combination, monitor closely for a diminished response to secretin. HMT levels were approximately 2 to 3 fold higher in patients with renal impairment than in healthy volunteers. Abiraterone Acetate: May increase the serum concentration of CYP2D6 Substrates. Management: Avoid concurrent use of abiraterone with CYP2D6 substrates that have a narrow therapeutic index whenever possible. If you take too much Detrol, call your doctor, or go to the hospital emergency room right away. Medicines are sometimes prescribed for conditions that are not in the patient information leaflet. Only use tolterodine tartrate extended-release capsules the way your doctor tells you. Do not share them with other people even if they have the same symptoms you have. They may harm them. Fluoxetine is a selective serotonin reuptake inhibitor and a potent inhibitor of CYP2D6 activity. Do not increase your dose or take this medication more often than directed. Your condition will not improve any faster and your risk of serious side effects may be increased. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. triamterene



Before taking tolterodine

The burning question in her life, she says, became: "How fast can I get to the bathroom? Pharmacokinetic studies revealed that tolterodine is metabolized at a slower rate in poor metabolizers than in extensive metabolizers; this results in significantly higher serum concentrations of tolterodine and in negligible concentrations of 5-HMT. Detrusitol is used for the treatment of the symptoms of overactive bladder syndrome. It is very important that your doctor check your progress at regular visits. Pharmaceuticals Inc. March, 2005. Leaking urine when you have the urge to urinate.



Have any stomach or intestinal problems

This occurs uncommonly occurs in less than 1 in 100 patients. The effect of tolterodine on QT interval prolongation has been found to correlate with tolterodine plasma concentrations. The QTc interval increase appears to be greater in CYP2D6 poor metabolizers than extensive metabolizers. These observations should be considered in clinical decisions to prescribe tolterodine for patients who are taking class IA or class III antiarrhythmic agents. Keep this leaflet. You may need to read it again. The two often coexist in women. The review does not make recommendations about the use of these drugs. low bonviva



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About tolterodine


Tolterodine adult dosage

Rentzhog L, Stanton SL, Cardozo L et al. Efficacy and safety of tolterodine in patients with detrusor instability: a dose-ranging study. Br J Urol. The 2 mg capsules are blue-green with symbol and 2 printed in white ink. Patients should be monitored for signs of anticholinergic CNS effects, particularly after beginning treatment or increasing the dose. Side Effects List Tolterodine TARTRATE ER side effects by likelihood and severity. If you miss a dose of tolterodine tartrate extended-release capsules, begin taking tolterodine tartrate extended-release capsules again the next day. Do not take 2 doses of tolterodine tartrate extended-release capsules in the same day.

What conditions does tolterodine treat

What is overactive bladder? Abdominal distension, ataxia, blurred vision, cardiac slowing followed by acceleration, CNS stimulation, coma, decreased intestinal peristalsis, delirium, dilated pupils, drowsiness, dry mouth, flushing, hallucinations, headache, hot skin, hypertension, hypotension, inhibition of sweating, palpitations, photophobia, restlessness, seizures, speech disturbances, stupor, thirst. Child-Pugh Class A or B is DETROL LA 2 mg once daily. CYP2D6 Inhibitors Strong: May decrease the metabolism of CYP2D6 Substrates.

Highlights for tolterodine

Administer orally without regard to meals. 1 17 18 23 See Food under Pharmacokinetics. Are pregnant or trying to become pregnant. It is not known if tolterodine tartrate extended-release capsules could harm your unborn baby. Take this medicine at the same time each day. Table 2 summarizes the mean change from baseline to steady state in corrected QT interval QTc relative to placebo at the time of peak tolterodine 1 hour and moxifloxacin 2 hour concentrations. In a study presented at the American Urological Association meeting in 2007, Swiss researchers reported success in using Botox in 180 women and men with overactive bladder. Within two weeks, 87% had significant improvement in symptoms, the Swiss reported. Urgency disappeared in 75% and in 84%.

Tolterodine dosage

Take this medicine only as directed. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. Also, do not change your dose without checking first with your doctor. Overdosage with Detrol can potentially result in severe central anticholinergic effects and should be treated accordingly. Cimetropium: Anticholinergic Agents may enhance the anticholinergic effect of Cimetropium. Read the Patient Information that comes with Tolterodine Tartrate Tablets before you start using it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your doctor about your condition or your treatment. Only your doctor can determine if treatment with Tolterodine Tartrate Tablets is right for you.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. The frequency of discontinuation due to adverse events was highest during the first 4 weeks of treatment. Similar percentages of patients treated with tolterodine tartrate extended-release capsules or placebo discontinued treatment due to adverse events. Extensively hepatic, primarily via CYP2D6 to 5-hydroxymethyltolterodine active and 3A4 usually minor pathway. In patients with a genetic deficiency of CYP2D6, metabolism via 3A4 predominates. generic eprex mail order usa

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